AI Article Synopsis
- The Hippo pathway consists of key proteins that regulate cell growth, survival, and tumorigenesis, influencing tissue and organ size.
- Ferroptosis is a type of cell death driven by iron-dependent reactive oxygen species and depletion of certain fatty acids, resulting from oxidative stress imbalance.
- The article discusses how the Hippo pathway interacts with ferroptosis, suggesting potential strategies for managing cell survival and tumor treatments.
Article Abstract
The role of Hippo pathway in ferroptosis The Hippo pathway is mainly composed of mammalian serine/threonine (Ste20)like kinases 1/2 (MST1/2), large tumor suppressor 1/2 (LATS1/2), and transcriptional coactivator Yes-associated protein (YAP), and is closely related to cell growth, survival, proliferation, and migration; tissue and organ size control; and tumorigenesis and development. Ferroptosis is a regulated form of cell death characterized by the accumulation of iron-dependent reactive oxygen species (ROS) and the depletion of plasma membrane polyunsaturated fatty acids (PUFAs), which is caused by the imbalance of oxidation and the antioxidant system. This article elaborates the role of Hippo pathway in ferroptosis, providing ideas for the regulation of cell fate and the treatment of tumors.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874674 | PMC |
| http://dx.doi.org/10.3389/fonc.2022.1107505 | DOI Listing |
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