AI Article Synopsis
- Herbal medicine has shown potential benefits for treating various diseases, but challenges arise from unclear active compounds and mechanisms.
- Metabolomics might help address these challenges by examining the metabolism of small molecules in herbal medicine.
- This review emphasizes using metabolomics and chinmedomics to evaluate efficacy, discover active ingredients, and explore therapeutic targets in herbal medicine.
Article Abstract
Evidence shows that herbal medicine (HM) could be beneficial for the treatment of various diseases. However, complexities present in HM due to the unclear bioactive compounds, mechanisms of action, undetermined targets for therapy, and nonspecific features for metabolism, are currently an obstacle for the progression of novel drug discovery. Metabolomics could be a potential tool to overcome these issues and for the understanding of HM from a small-molecule metabolism level. The chinmedomics-based metabolomics method assesses the overall metabolism of organisms with a holistic view and shows great potential for understanding metabolic pathways, evaluating curative effects, clarifying mechanisms, discovering active ingredients, and precision medicine. This review focuses on the efficacy evaluation, active ingredient discovery, and target exploration of HM based on metabolomics and chinmedomics.
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| http://dx.doi.org/10.1016/j.tem.2023.01.005 | DOI Listing |
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