AI Article Synopsis
- Hypertensive disorders of pregnancy (HDP) affect around 10% of pregnancies and can increase the risk of future cardiovascular disease (CVD) and chronic hypertension in women.
- The study analyzed data from 26,024 menopausal Japanese women, revealing that 4.6% had a history of HDP, with higher rates of dyslipidemia and diabetes in women who also had hypertension (HT).
- Women with a history of HDP alone showed a 1.61 times higher risk of CVD, while those with both HDP and HT had even greater risks (4.11 times), highlighting the need for monitoring pregnancy outcomes in women's health.
Article Abstract
Aim: Hypertensive disorders of pregnancy (HDP) are estimated to occur in up to 10% of all pregnancies and are associated with an increased risk of future cardiovascular disease (CVD) and chronic hypertension (HT). Therefore, we examined the impact of a history of HDP on CVD possibility in middle- and older-aged Japanese women.
Methods: We used the Tohoku Medical Megabank database to obtain the data of 26,024 menopausal women who were aged ≥ 50 years, had children, did not smoke, and did not have chronic kidney disease and to analyze the relationship between HDP history and CVD.
Results: A history of HDP was found in 4.6% of women. We divided the women into four groups according to the presence or absence of HDP and HT. The percentage of women with dyslipidemia, diabetes mellitus, and body mass index of ≥ 25 kg/m was the highest in the HDP＋ HT＋ group compared to the other groups (43.4%, 24.0%, and 45.2%, respectively). Adjusted odds ratio (OR) for the combined six CVD categories was higher for those with a history of HDP alone (OR [95% confidence interval [CI]]: 1.61 [1.03-2.53]). Moreover, the OR was significantly higher for those with combination with HDP history and HT (OR [95% CI]: 4.11 [3.16-5.35]). The prevalence of individual CVD was also the highest in the HT＋ HDP＋ group.
Conclusion: An HDP history can influence the risk of CVD in Japanese women, indicating the importance of information about pregnancy outcomes in health management.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564666 | PMC |
| http://dx.doi.org/10.5551/jat.63816 | DOI Listing |
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