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Outcomes in hematopoetic cell transplantation in the setting of mold infections in patients with chronic granulomatous disease.
Bone Marrow Transplant
November 2024
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Chronic granulomatous disease (CGD) is a disorder of immunity characterized by phagocyte dysfunction. Mold infections in patients with CGD are often severe and disseminated. We present patient characteristics, microbiological data, and outcomes for 26 patients with CGD who received hematopoietic cell transplantation (HCT) or gene therapy-modified cells (GT) between 2008 and 2019, with proven fungal infection either before or during their transplant.
View Article and Find Full Text PDFApplication of small animal ultrasound imaging technology for identification of polycystic ovary syndrome in a mouse model.
Biochem Biophys Res Commun
November 2024
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, 750004, China; Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan, 750004, China. Electronic address:
Background And Aims: Polycystic ovary syndrome (PCOS) is a hormonal disorder common among women of reproductive age, characterized by irregular menstrual periods, elevated levels of androgens, and polycystic ovaries, leading to various symptoms and complications such as infertility, metabolic issues, and increased risk of diabetes and heart disease. This study aimed to compare traditional histological methods and ultrasound imaging for consistency in identifying PCOS in a mouse model. The shortest time to construct the PCOS model using letrozole was determined.
View Article and Find Full Text PDFIn Vivo Confocal Microscopy Findings of a Rare Keratitis.
Ocul Immunol Inflamm
December 2024
Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Purpose: To report a rare case of fungal keratitis caused by , highlighting its unique morphological features using in vivo confocal microscopy (IVCM).
Methods: This was a retrospective case report. A 66-year-old man presented with foreign body sensation and blurred vision in his left eye for over 10 months.
Filgotinib in Active Noninfectious Uveitis: The HUMBOLDT Randomized Clinical Trial.
JAMA Ophthalmol
September 2024
Legacy Devers Eye Institute, Portland, Oregon.
Article Synopsis
- - Noninfectious uveitis is a major cause of vision loss and there is a need for better treatment options, prompting the investigation of filgotinib, a JAK1 inhibitor, for this condition.
- - The HUMBOLDT trial was a phase 2 study involving 74 participants, aged 18 and older, with active noninfectious uveitis, comparing filgotinib to a placebo over 52 weeks.
- - Results showed that 37.5% of those on filgotinib experienced treatment failure by week 24, significantly lower than the 67.6% for placebo, indicating that filgotinib may be an effective option for treating this illness.
Candida Isolation During COVID-19: Microbiological Findings of a Prospective Study in a Regional Hospital.
Arch Med Res
September 2024
Medical Bacteriology Laboratory. Department of Microbiology, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico; General Microbiology Laboratory, Department of Microbiology, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico. Electronic address:
Background: Prolonged hospitalization due to the COVID-19 pandemic gathered risk factors for developing invasive candidiasis.
Aim: To describe Candida spp. isolated from patients with clinical suspicion of COVID treated in a public hospital specialized in COVID-19 during the pandemic, considering the susceptibility profiles and the risk factors related to the species detected in a positive yeast culture.
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