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Glucagon-like peptide 2 stimulates glucagon secretion, enhances lipid absorption, and inhibits gastric acid secretion in humans.
Gastroenterology
January 2006
Department of Medicine I, St. Josef-Hospital, Ruhr-University, Bochum, Germany.
Background & Aims: The gut-derived peptide glucagon-like peptide 2 (GLP-2) has been suggested as a potential drug candidate for the treatment of various intestinal diseases. However, the acute effects of GLP-2 on gastric functions as well as on glucose and lipid homeostasis in humans are less well characterized.
Methods: Fifteen healthy male volunteers were studied with the intravenous infusion of GLP-2 or placebo over 120 minutes in the fasting state, and pentagastrin-stimulated gastric acid output was assessed.
Stimulatory effect of endogenous orexin A on gastric emptying and acid secretion independent of gastrin.
Regul Pept
December 2005
Division of Surgery, Danderyd Hospital, Karolinska Institutet, Danderyd Hospital, SE-182 88 Stockholm, Sweden.
Orexin A (OXA) increases food intake and inhibits fasting small bowel motility in rats. The aim of this study was to examine the effect of exogenous OXA and endogenous OXA on gastric emptying, acid secretion, glucose metabolism and distribution of orexin immunoreactivity in the stomach. Rats equipped with a gastric fistula were subjected to intravenous (IV) infusion of OXA or the selective orexin-1 receptor (OX1R) antagonist SB-334867-A during saline or pentagastrin infusion.
View Article and Find Full Text PDFEffect of peripherally administered ghrelin on gastric emptying and acid secretion in the rat.
Regul Pept
November 2005
Department of Surgery, Karolinska Institutet Danderyd Hospital, SE-182 88 Stockholm, Sweden.
Ghrelin is a gut peptide that is secreted from the stomach and stimulates food intake. There are ghrelin receptors throughout the gut and intracerebroventricular ghrelin has been shown to increase gastric acid secretion. The aim of the present study was to examine the effects of peripherally administered ghrelin on gastric emptying of a non-nutrient and nutrient liquid, as well as, basal and pentagastrin-stimulated gastric acid secretion in awake rats.
View Article and Find Full Text PDFGlucagon-like peptide-1 in the pathogenesis of obesity.
Drug News Perspect
March 1998
Division of Surgery, Karolinska Institute, Danderyd Hospital, Sweden.
The recently discovered gut peptide glucagon-like peptide-1 (GLP-1) is one of many peptides implicated in the short-term regulation of appetite. GLP-1 is a 30-amino-acid peptide that is produced in and secreted from the L cells of the intestinal mucosa after intake of a mixed meal. The amino acid sequence of GLP-1 is highly conserved and all mammals studied to date have identical GLP-1 sequences.
View Article and Find Full Text PDFPharmacologic interventions in nuclear radiology: indications, imaging protocols, and clinical results.
Radiographics
September 2002
Division of Nuclear Medicine, Department of Radiology, Keck School of Medicine, University of Southern California, 1200 N State St, GNH 5250, Los Angeles, CA 90033, USA.
Nuclear radiology is valuable in assessing pathophysiology of a variety of organ systems. Pharmacologic interventions are often employed in radionuclide imaging to monitor the physiologic changes, which in turn facilitate the diagnosis. Metoclopramide, erythromycin, and cisapride have been used for gastric emptying studies.
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