The aetiology of recurrent abdominal pain in children (RAP) remains unclear. Some features of this syndrome suggest that an opiate-like mechanism may be involved. The evidence for this is reviewed, and it is hypothesised that RAP may result from a differential gastrointestinal response to stress mediated by the endogenous opiate system.
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| http://dx.doi.org/10.1016/0304-3959(87)91077-3 | DOI Listing |
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