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Interstitial Lung Disease Associated with Anti-Ku Antibodies: A Case Series of 19 Patients.
J Clin Med
January 2025
Department of Respiratory Medicine, National Reference Center for Rare Pulmonary Diseases, Louis Pradel Hospital, Hospices Civils de Lyon, European Reference Network (ERN)-LUNG, 28 Avenue Doyen Lepine, 69677 Lyon, France.
Antibodies against Ku have been described in patients with various connective tissue diseases. The objective of this study was to describe the clinical, functional, and imaging characteristics of interstitial lung disease in patients with anti-Ku antibodies. : This single-center, retrospective observational study was conducted at a tertiary referral institution.
View Article and Find Full Text PDFImpact of autoantibody status on stratifying the risk of organ involvement and mortality in SSc: experience from a multicentre French cohort of 1605 patients.
RMD Open
November 2024
Department of Internal Medicine, Infectious Diseases, and Clinical Immunology, University Hospital Centre Reims, Reims, Grand Est, France.
Article Synopsis
- Systemic sclerosis (SSc) is a rare autoimmune disease classified into two groups based on skin involvement; this study investigates the role of autoantibody profiles in predicting organ damage and mortality compared to skin phenotype.
- Researchers analyzed data from 1,605 patients across seven French hospitals, focusing on autoantibodies and their correlation with various organ issues and death rates.
- Findings reveal that specific autoantibodies are strongly linked to serious complications like interstitial lung disease and renal crisis, while skin phenotype alone does not effectively predict patient outcomes.
Not Just Myocarditis: Mixed Connective Tissue Disease (MCTD) and Overlap Myositis With Anti-Ku Positivity in a Young Male With Shortness of Breath.
Cureus
October 2024
Rheumatology, University of Ottawa, Ottawa, CAN.
Mixed connective tissue disease (MCTD) is an autoimmune disorder characterized by high levels of anti-U1 ribonucleoprotein (RNP) antibodies and overlapping clinical features of autoimmune diseases, such as systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and polymyositis (PM). Anti-Ku antibodies have been associated with overlap syndromes, which can present with symptoms such as Raynaud's phenomenon, arthritis, and myositis. A 19-year-old male athlete presented with myositis, notable for cardiac involvement.
View Article and Find Full Text PDFComparison of Lineblot and Immunoprecipitation Methods in the Detection of Myositis-Specific and Myositis-Associated Antibodies in Patients with Idiopathic Inflammatory Myopathies: Consistency with Clinical Diagnoses.
Diagnostics (Basel)
September 2024
Rheumatology and Clinical Immunology Unit, ERN ReCONNET Centre, ASST Spedali Civili, Piazzale Spedali Civili, 1, 25124 Brescia, Italy.
Article Synopsis
- * A total of 69 patients were analyzed, showing high concordance for certain antibodies (like anti-Ku and anti-PM/Scl) and moderate agreement for others (like anti-Jo1 and anti-Mi-2), while some antibodies could only be detected by one method.
- * The results suggest that LB may be more sensitive for detecting multiple MSAs and specific antibodies, while IP performs well for dermatomyositis-associated MSAs
A challenging case of hemolytic disease of the fetus and newborn (HDFN) due to anti-Ku in a K (Kell) mother.
Immunohematology
September 2024
5Laboratory and Blood Services Department, National Heart Institute, Kuala Lumpur, Malaysia.
Hemolytic disease of the fetus and newborn (HDFN) due to an antibody in the Kell blood group system can be associated with severe fetal anemia. This case report details the challenges of managing a Kell mother with anti-Ku that affected her fetus/newborn. A gravida 4 para 3 woman at term underwent an emergency lower caesarean section because of fetal distress.
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