AI Article Synopsis
- Clear cell (hemangioblastoma-like) stromal tumor of the lung (CCSTL) is a rare type of lung tumor, and recent findings link it to the YAP1-TFE3 gene fusion.
- A case study featured a 57-year-old male with a 45 mm lung nodule, showing specific microscopic and immunohistochemical characteristics.
- The study's results reinforce the idea that the YAP1-TFE3 fusion is a typical feature of CCSTL, potentially helping in its classification and understanding.
Article Abstract
Background: Clear cell (hemangioblastoma-like) stromal tumor of the lung (CCSTL) is a rare pulmonary neoplasm. Recently, 9 cases of CCSTL harboring the YAP1-TFE3 gene fusion have been described, and it has been suggested that this aberration could be a characteristic feature of this tumor.
Case Presentation: We here report another case of CCSTL in a 57-year-old male, which presented as a solitary lung nodule 45 mm in the greatest dimension. Microscopically, the tumor consisted of epithelioid to spindled cells with mild-to-moderate nuclear atypia, finely granular or vesicular chromatin, and small nucleoli. Nuclear indentations were a common finding. There were up to 3 mitoses per 10 HPF. The cytoplasm was slightly eosinophilic or clear. Scattered non-tumor large multinucleated cells were present. Immunohistochemically, the tumor cells showed diffuse positivity for TFE3, CD10, vimentin, and IFITM1. Other markers examined were negative, and the expression of lineage-specific markers was not found. NGS analysis revealed a fusion transcript of the YAP1 and TFE3 genes, and a pathogenic variant of the MUTYH gene.
Conclusion: Our finding supports the recent data suggesting that CCSTL represents a distinct entity characterized by the recurrent YAP1-TFE3 fusion.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881279 | PMC |
| http://dx.doi.org/10.1186/s13000-023-01304-0 | DOI Listing |
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