AI Article Synopsis
- Aberrant signaling pathways can disrupt how hematopoietic stem cells (HSCs) grow and differentiate, potentially leading to diseases like Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML).
- Phosphoinositides (PIs) are a specific type of inositol phospholipid that play a crucial role in regulating these signaling pathways.
- Issues with the regulation of enzymes like Phospholipase C (PLC) beta1 and PLCgamma1, as well as the PI3K/Akt/mTOR signaling pathway, are particularly important in the development of these blood disorders.
Article Abstract
Aberrant signaling pathways regulating proliferation and differentiation of hematopoietic stem cells (HSCs) can contribute to disease pathogenesis and neoplastic growth. Phosphoinositides (PIs) are inositol phospholipids that are implicated in the regulation of critical signaling pathways: aberrant regulation of Phospholipase C (PLC) beta1, PLCgamma1 and the PI3K/Akt/mTOR pathway play essential roles in the pathogenesis of Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML).
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| http://dx.doi.org/10.1016/j.jbior.2023.100955 | DOI Listing |
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