AI Article Synopsis
- The effectiveness of statins for stroke prevention is debated due to possible side effects such as myalgia and muscle issues.
- Research indicates that statin therapy may reduce the risk of ischemic strokes and help with recovery after a stroke due to its neuroprotective properties.
- The study aims to examine how statins can improve mitochondrial function, potentially offering a new therapeutic strategy for stroke prevention and treatment.
Article Abstract
In clinical settings, the benefit of statin for stroke is debatable as regular statin users may suffer from myalgia, statin-associated myopathy (SAM), and rarely rhabdomyolysis. Studies suggest that patients on statin therapy show lesser vulnerability toward ischemic stroke and post-stroke frailty. Both pre- and post-treatment benefits of statin have been reported as evident by its neuroprotective effects in both cases. As mitochondrial dysfunction following stroke is the fulcrum for neuronal death, we hereby explore the role of statin in alleviating mitochondrial dysfunction by regulating the mitochondrial dynamics. In the present study, we intend to evaluate the role of statin in modulating cardiolipin-mediated mitochondrial functionality and further providing a therapeutic rationale for repurposing statins either as preventive or an adjunctive therapy for stroke.
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| http://dx.doi.org/10.1021/acschemneuro.2c00645 | DOI Listing |
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