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Asthma Biologics Across the T2 Spectrum of Inflammation in Severe Asthma: Biomarkers and Mechanism of Action.
J Asthma Allergy
January 2025
Amgen Inc., Thousand Oaks, CA, USA.
Airway inflammation, a hallmark feature of asthma, drives many canonical features of the disease, including airflow limitation, mucus plugging, airway remodeling, and hyperresponsiveness. The T2 inflammatory paradigm is firmly established as the dominant mechanism of asthma pathogenesis, largely due to the success of inhaled corticosteroids and biologic therapies targeting components of the T2 pathway, including IL-4, IL-5, IL-13, and thymic stromal lymphopoietin (TSLP). However, up to 30% of patients may lack signatures of meaningful T2 inflammation (ie, T2 low).
View Article and Find Full Text PDFDeveloping a dual-antibody Sandwich ELISA and LFIA for detecting the cashew allergen Ana o 3 in foods.
Food Chem
January 2025
State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China; Sino-German Joint Research Institute, Nanchang University, Nanchang 330047, China. Electronic address:
Cashews are popular snacks but pose risks to allergic individuals due to Ana o 3 protein. Rapid, accurate detection methods for Ana o 3 are limited. This study developed two detection methods for Ana o 3 allergen.
View Article and Find Full Text PDFHypersensitivity to Lanolin: An Old-New Problem.
Life (Basel)
November 2024
Department of Allergology, Clinical Immunology and Internal Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Ul. Ujejskiego 75, 85-168 Bydgoszcz, Poland.
Lanolin is a fatty substance derived from sheep's fleece. The ancient Greeks used the moisturizing and skin-protective properties of this substance. The technique of industrial production of lanolin was developed in Germany in the 19th century.
View Article and Find Full Text PDF[Mechanisms of allergen-specific immunotherapy].
Nihon Yakurigaku Zasshi
January 2025
Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development.
Allergen-specific immunotherapy (AIT) has been a longstanding treatment for allergic diseases. Historically, subcutaneous immunotherapy was the main approach, but with the development of sublingual preparations, which are associated with fewer systemic side effects, sublingual immunotherapy is gaining global popularity. In Japan, the approval of standardized sublingual immunotherapy preparations in 2014 has significantly accelerated its adoption.
View Article and Find Full Text PDFOccupational anaphylaxis to food.
Med Pr
December 2024
Medical University of Silesia, Katowice, Poland (Department of Internal Medicine, Allergology and Clinical Immunology).
Increasing incidence and importance of allergies in everyday life leads to bigger impact on the professional lives of patients. Continuous exposure to various allergens may be a trigger factor of development allergic diseases, even anaphylactic shock. This paper summarizes available knowledge of occupational anaphylaxis to food.
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