Osteoradionecrosis of the Skull Base in Nasopharyngeal Carcinoma.

Radiol Imaging Cancer

From the Department of Medical Imaging (M.J.G., G.D., R.M.) and Department of Otolaryngology and Head and Neck Surgery (C.H.L.), University of Arizona, Tucson, AZ 85711; and Midwestern University Arizona College of Osteopathic Medicine, Glendale, Ariz 85308 (S.P.J.).

Published: January 2023

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896225PMC
http://dx.doi.org/10.1148/rycan.220159DOI Listing

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Article Synopsis
  • - The study aimed to compare the fractal dimension (FD) and lacunarity of mandibular bone in patients with osteoradionecrosis (ORN) versus those without, using digital panoramic radiographs and ImageJ software for analysis.
  • - A total of 25 patients were divided into two groups (14 with ORN and 11 without), and while FD and lacunarity values were similar across groups, certain thresholds were identified that helped differentiate between the two populations.
  • - Although the differences in FD and lacunarity were not statistically significant, the effect sizes suggest potential clinical relevance, indicating that these measurements could be useful in evaluating bone health post-radiotherapy.
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Materials And Methods: Patients with segmental mandibular resection and immediate reconstruction with osseous free flaps due to advanced OSCC between 2012 and 2022 were analyzed retrospectively regarding overall (OS), disease-free survival (DFS), local failure-free survival (LFFS), the need for secondary surgeries as well as flap complications and compared between patients with and without PORT in a matched-pair approach with occurrence of flap complications as a primary endpoint.

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