Purpose: It is shown that the steady state of rapid, TR-periodic steady-state free precession (SSFP) sequences at small to moderate flip angles exhibits a universal, approximate scaling law with respect to variations of . Implications for the accuracy and precision of relaxometry experiments are discussed.
Methods: The approximate scaling law is derived from and numerically tested against known analytical solutions. To assess the attainable estimator precision in a typical relaxometry experiment, we calculate the Cramér-Rao bound (CRB) and perform Monte Carlo (MC) simulations.
Results: The approximate universal scaling holds well up to moderate flip angles. For pure steady state relaxometry, we observe a significant precision penalty for simultaneous estimation of and , whereas good estimates can be obtained without even knowing the correct actual flip angle.
Conclusion: Simultaneous estimation of and from a set of SSFP steady states alone is not advisable. Apart from separate measurements, the problem can be addressed by adding transient state information, but, depending on the situation, residual effects due to the scaling may still require some attention.
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