Rapid kinetics, complex and diverse reaction intermediates, and difficult screening make the study of assembly mechanisms of high-nuclearity lanthanide clusters challenging. Here, we synthesize a double-cage dysprosium cluster [Dy(HL)(OAc)(O)(OH)(HO)]·6HO·6CHOH·7CHCN (Dy) by using a multidentate chelate-coordinated diacylhydrazone ligand. Two Dy cages are included in the Dy structure, which are connected via an OAc moiety. The core of Dy is composed of 8 triangular Dy and 12-fold linear Dy units. We further change the alkali added in the reaction system and successfully obtain a single cage-shaped cluster [Dy(HL)(OAc)(OH)(HO)]·2OH·10HO·12CHOH·13CHCN (Dy) with a perfect spherical cavity, which could be considered an intermediate in Dy formation. Time-dependent, high-resolution electrospray ionization mass spectrometry (HRESI-MS) is used to track the formation of Dy. A possible self-assembly mechanism is proposed. We track the formation of Dy and the six intermediate fragments are screened.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814749 | PMC |
| http://dx.doi.org/10.1038/s42004-020-0276-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The transcriptional response of cortical neurons to concussion reveals divergent fates after injury.
Nat Commun
January 2025
Unit on the Development of Neurodegeneration, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Traumatic brain injury (TBI) is a risk factor for neurodegeneration, however little is known about how this kind of injury alters neuron subtypes. In this study, we follow neuronal populations over time after a single mild TBI (mTBI) to assess long ranging consequences of injury at the level of single, transcriptionally defined neuronal classes. We find that the stress-responsive Activating Transcription Factor 3 (ATF3) defines a population of cortical neurons after mTBI.
View Article and Find Full Text PDFThe polymerase gamma (POLG) gene mutation is associated with mitochondria and metabolism disorders, resulting in heterogeneous responses to immunological activation and posing challenges for mitochondrial disease therapy. Optical metabolic imaging captures the autofluorescent signal of two coenzymes, NADH and FAD, and offers a label-free approach to detect cellular metabolic phenotypes, track mitochondria morphology, and quantify metabolic heterogeneity. In this study, fluorescence lifetime imaging (FLIM) of NAD(P)H and FAD revealed that POLG mutator macrophages exhibit a decreased NAD(P)H lifetime, and optical redox ratio compared to the wild-type macrophages, indicating an increased dependence on glycolysis.
View Article and Find Full Text PDFSleep entails significant changes in cerebral hemodynamics and metabolism. Yet, the way these processes evolve throughout wakefulness and sleep and their spatiotemporal dependence remain largely unknown. Here, by integrating a novel functional PET technique with simultaneous EEG-fMRI, we reveal a tightly coupled temporal progression of global hemodynamics and metabolism during the descent into NREM sleep, with large hemodynamic fluctuations emerging as global glucose metabolism declines, both of which track EEG arousal dynamics.
View Article and Find Full Text PDFPriority effects, nutrition and milk glycan-metabolic potential drive subspecies dynamics in the infant gut microbiome.
PeerJ
January 2025
Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Amsterdam, Netherlands.
Background: The initial colonization of the infant gut is a complex process that defines the foundation for a healthy microbiome development. is one of the first colonizers of newborns' gut, playing a crucial role in the healthy development of both the host and its microbiome. However, exhibits significant genomic diversity, with subspecies ( subsp.
View Article and Find Full Text PDFEvolution Driven Microscale Combinatorial Chemistry in Intracellular Mimicking Droplets to Engineer Thermostable RNA for Cellular Imaging.
Small
January 2025
School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Fluorescent light-up aptamer/fluorogen pairs are powerful tools for tracking RNA in the cell, however limitations in thermostability and fluorescence intensity exist. Current in vitro selection techniques struggle to mimic complex intracellular environments, limiting in vivo biomolecule functionality. Taking inspiration from microenvironment-dependent RNA folding observed in cells and organelle-mimicking droplets, an efficient system is created that uses microscale heated water droplets to simulate intracellular conditions, effectively replicating the intracellular RNA folding landscape.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!