The activation of very inert small molecules generally requires highly reactive activating species, but the high energy of these species makes their regeneration, and thus also catalytic turnover of the reaction, difficult to achieve. Here, the authors highlight the formidable challenge of overcoming the tradeoff between activating power and catalytic turnover in the context of main-group ambiphiles.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814040 | PMC |
http://dx.doi.org/10.1038/s42004-020-00371-4 | DOI Listing |
PLoS Negl Trop Dis
March 2025
Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America.
Trypanosoma cruzi is a single-celled eukaryotic parasite responsible for Chagas disease, a major cause of morbidity and mortality in Central and South America. While the host-pathogen interactions of T. cruzi have been extensively studied in vertebrate models, investigations into its interactions within its insect host remain limited.
View Article and Find Full Text PDFJ Colloid Interface Sci
March 2025
State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources, College of Chemistry, Xinjiang University, Urumqi 830017, Xinjiang, PR China.
Activation of inert molecules and stabilization of intermediates during photocatalytic reactions in Bi-based photocatalysts can be achieved by shifting the band center of Bi 6p orbital but the underlying mechanism requires further investigation. Herein, halogen-doping BiOCl photocatalysts were synthesized using a simple solvothermal method and experimental results showed that BiOClBr and BiOClI photocatalysts not only achieved a maximum CO evolution rate of 270 and 227 µL·g·h with a high selectivity of 97 %, but also effectively removed environmental pollutants. Density functional theory calculations demonstrate that halogen-doping shifted the band center of the Bi 6p orbital in BiOCl towards the Fermi level, leading to the delocalization of the Bi 6p orbital.
View Article and Find Full Text PDFACS Appl Mater Interfaces
March 2025
National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu 610064, Sichuan, China.
Structural defects and biological inertness significantly impair the integration of titanium alloy implants and bone tissues. In spinal internal fixation, the issue of pedicle screw loosening or fracture caused by poor integration urgently needs solving. In this study, we utilized 3D printing technology to custom fabricate a structurally optimized porous pedicle screw with the aim of enhancing bone regeneration and integration at the defect site, thereby enhancing the biological fixation of the implant .
View Article and Find Full Text PDFCureus
February 2025
Ophthalmology, Dr. Suresh Babu Eye Foundation, Kasaragod, IND.
Intravitreal anti-vascular endothelial growth factor (VEGF) injections are a cornerstone treatment for various retinal conditions, including diabetic macular edema and age-related macular degeneration. While generally safe, these injections can introduce unintended substances, such as silicone oil droplets, into the vitreous cavity due to the silicone-based lubricant used in syringe manufacturing. Although frequently asymptomatic, silicone oil droplets can occasionally cause significant visual disturbances and discomfort.
View Article and Find Full Text PDFJ Nat Prod
March 2025
University of Ljubljana, Biotechnical Faculty, Department of Food Science and Technology, 1000 Ljubljana, Slovenia.
The medically important immunosuppressant FK506 is a structurally complex macrolactone biosynthesized by a combined polyketide synthase and a nonribosomal peptide synthetase enzyme complex. Its acyltransferase domain 4 (AT4) selects an unusual extender unit, resulting in an allyl moiety on carbon 21 of the macrolactone backbone. Based on the AT4 domain, chemobiosynthetic processes have been developed that enable the introduction of diverse moieties at the carbon 21 position.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!