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Future potential of in vitro maturation including fertility preservation. | LitMetric

Future potential of in vitro maturation including fertility preservation.

Fertil Steril

Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, University Hospital of Copenhagen, Copenhagen, Denmark; Faculty of Health and Medical Science, Copenhagen University, Copenhagen, Denmark. Electronic address:

Published: April 2023

AI Article Synopsis

  • In vitro maturation (IVM) of oocytes from small antral follicles shows promise for procreation in many mammals but faces challenges in humans due to unique maturation processes and access to immature oocytes.
  • Recent research highlights factors like oocyte diameter, follicle size, and hormone levels that influence the effectiveness of IVM, aiming to address these challenges and improve outcomes.
  • The study suggests that refining the culture medium used in IVM can better replicate the natural follicular environment, which may enhance both nuclear and cytoplasmic maturation of human oocytes.

Article Abstract

In several mammalian species, oocytes from small antral follicles after in vitro maturation (IVM) are successfully used for procreation. Humans are the exception, mainly because of limited access to immature oocytes and because oocyte maturation is uniquely regulated in women. With the introduction of cryopreservation of the ovarian cortex for fertility preservation, immature oocytes from small antral follicles in the medulla are now available for developing IVM on the basis of actual human studies. This review presents recent findings in favor of developing human IVM, including the oocyte diameter, follicle size from which the immature oocytes are collected, necessary level of follicle-stimulating hormone and luteinizing hormone to accelerate IVM, and secretion of factors from the cumulus-oocyte complex that affect the way oocyte maturation takes place. Furthermore, on the basis of studies in human granulosa cells and follicle fluid collected during the final maturation of follicles in vivo, a number of signal transduction pathways and hormone levels active during physiological conditions have been identified, providing new candidates and ways to improve the current IVM platform. Furthermore, it is suggested that the small droplet of culture medium in which IVM is performed mimics the hormonal milieu within a follicle created by the somatic cells and oocyte in vivo and may be used to advance oocyte nuclear and cytoplasmic maturation. Collectively, we envision that a continued research effort will develop a human IVM platform equally effective as for other mammalian species.

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Source
http://dx.doi.org/10.1016/j.fertnstert.2023.01.027DOI Listing

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