AI Article Synopsis
- The study aimed to identify factors that predict positive outcomes in patients with early acute ischemic stroke (AIS) who have a low Alberta Stroke Program Early CT Score (ASPECTS) after undergoing endovascular thrombectomy (EVT).
- Researchers reviewed 59 patients' data from October 2019 to April 2021 and categorized them into good and poor outcome groups based on their modified Rankin Score (mRS) at 90 days.
- The results showed that smaller ischemic core volume, lower NIHSS score, and shorter time from stroke onset to reperfusion were significant independent predictors of favorable outcomes in patients with ASPECTS < 6 after EVT.
Article Abstract
Objective: The standard for computed tomography perfusion (CTP) assessment has not been well established in early acute ischemic stroke (AIS). We aimed to examine the prognostic factors for good outcomes in patients who received CTP, with an Alberta Stroke Program Early CT Score (ASPECTS) < 6 after endovascular thrombectomy (EVT) in the early time window (0-6 h).
Methods: We retrospectively reviewed 59 patients who met the criteria from October 2019 to April 2021. Based on the modified Rankin Score (mRS) at 90 days, the patients were divided into a good outcome group (mRS 0-2) and a poor outcome group (mRS 3-6). Baseline and procedural characteristics were collected for unilateral and multivariate regression analyses to explore the influencing factors for good outcomes.
Results: Of the 59 patients included, good outcomes were observed in 21 (35.6%). Multivariate logistic regression analysis showed that smaller ischemic core volume (odds ratio [OR]: 0.950; 95% CI: 0.908-0.994; P = 0.026), lower National Institutes of Health Stroke Scale (NIHSS) score (OR: 0.750; 95% CI: 0.593-0.949; P = 0.017) and shorter stroke onset to reperfusion time (ORT) (OR: 0.981; 95% CI: 0.966-0.996; P = 0.016) were independent predictors for good outcomes at 90 days.
Conclusion: Smaller ischemic core volume based on CTP, lower NIHSS score and shorter ORT were significant independent predictors of good outcomes in patients with ASPECTS < 6 in the early time window after EVT.
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| http://dx.doi.org/10.1016/j.clineuro.2023.107605 | DOI Listing |
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