To identify differential methylation related to prescribed opioid use. This study examined whether blood DNA methylation, measured using Illumina arrays, differs by recent opioid medication use in four population-based cohorts. We meta-analyzed results (282 users; 10,560 nonusers) using inverse-variance weighting. Differential methylation (false discovery rate <0.05) was observed at six CpGs annotated to the following genes: , , , , and . Integrative epigenomic analyses linked implicated loci to regulatory elements in blood and/or brain. Additionally, 74 CpGs were differentially methylated in males or females. Methylation at significant CpGs correlated with gene expression in blood and/or brain. This study identified DNA methylation related to opioid medication use in general populations. The results could inform the development of blood methylation biomarkers of opioid use.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979153 | PMC |
| http://dx.doi.org/10.2217/epi-2022-0353 | DOI Listing |
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