The iminoacylation of alkenes via photoredox N-heterocyclic carbene catalysis is developed with the employment of alkene-tethered α-imino-oxy acids and acyl imidazoles. The corresponding substituted 3,4-dihydro-2-pyrroles were afforded in moderate to good yields with good to high diastereoselectivities in most cases. The reaction involves the 5--trig radical cyclization of an alkene-tethered iminyl radical and the following coupling with a ketyl radical from acyl imidazole under NHC catalysis.
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| http://dx.doi.org/10.1021/acs.orglett.3c00006 | DOI Listing |
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