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Biomarkers.
Alzheimers Dement
December 2024
Sistema Nacional de Investigación (SNI), Panamá, Panamá, Panama.
Background: We are conducting a biomarker-based study to describe the demographic and biomarker profiles of Panamanians. The objective of this report is to present the main findings on CSF, genetic and serological biomarkers' distribution and their association with cognition in a cohort of elderly people in Panama.
Method: Informed consent was applied to all participants, demographic data, medical history, and neuropsychological and functional status were collected, and non-fasting blood samples were obtained.
Public Health.
Alzheimers Dement
December 2024
Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Background: Currently, most clinical services focus on dementia diagnosis rather than prevention, despite evidence showing benefits of preventative interventions. People often present with memory problems before having dementia, or when in the early stages and are motivated to adopt preventive lifestyle strategies to slow decline. To address gaps in clinical services we set up the Bristol Brain Health Clinic (BHC) in 2017.
View Article and Find Full Text PDFAlzheimer's Imaging Consortium.
Alzheimers Dement
December 2024
Cognitive, Clinical and Computational Neuroscience (CCCN) Center of Excellence, Chulalongkorn University, Bangkok, Thailand.
Background: Tauopathy is recognized not only as a pathological substrate but also exhibits a robust correlation with the clinical manifestations of dementia, leading to diverse neuropsychiatric manifestation. However, human brain functions as networks rather than modules. The conventional query of 'Where is the lesion (regionally)?' may inadequately capture the entirety of dementia manifestations.
View Article and Find Full Text PDFUnveiling the Mimicker: A Case Report of Ocular Neurosyphilis.
Cureus
December 2024
Internal Medicine, Florida International University, Herbert Wertheim College of Medicine, Miami, USA.
Syphilis, an infection caused by , is well known for its ability to mimic other diseases across various organ systems, complicating timely diagnosis. Ocular syphilis, though rare, is a severe manifestation that can closely resemble other eye conditions, making early identification challenging. When conventional treatments fail to improve symptoms, considering syphilis in the differential diagnosis becomes crucial to avoid further complications.
View Article and Find Full Text PDFAtypical Oral Mucosal Lesions in Syphilis: A Case Report Highlighting the Diagnostic and Therapeutic Aspects of the "Great Imitator".
Cureus
December 2024
General and Oncological Dermatology Ward with a Day Care Unit, Provincial Hospital, Opole, POL.
The diagnostic process and discrimination of mucosal lesions present a formidable challenge for numerous clinicians, primarily attributable to the common overlap of clinical manifestations observed across various categories, including infectious, autoimmune, connective tissue, and systemic vascular inflammatory diseases. In cases of mucosal lesions, syphilis presents distinctive characteristics that can help clinicians differentiate it from other conditions. The most common manifestation of primary syphilis is mostly a painless, firm, indurated ulcer known as a chancre, which typically appears at the site of inoculation, with enlargement of regional lymph nodes.
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