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| http://dx.doi.org/10.3389/fcell.2022.1102381 | DOI Listing |
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Understanding disorders of the human nervous system: How fish models reveal disease mechanisms from single molecules to behavior (part 2).
Dev Growth Differ
January 2025
Graduate School of Science and Engineering, Saitama University, Saitama, Japan.
The usefulness of zebrafish for understanding the human nervous system is exemplified by the articles in part 1. The virtual special issue part 2 not only covers more work using this well-established species, but also highlights that other fish species may serve as alternative or more appropriate models, due to unique biological or evolutionary characteristics, to explore genetic and molecular mechanisms of neurological and psychiatric disorders.
View Article and Find Full Text PDFSpatiotemporal control of translation in live zebrafish embryos via photoprotected mRNAs.
Commun Chem
January 2025
Institute of Biochemistry, University of Münster, Münster, Germany.
Translation of mRNA into protein is a fundamental process and tightly controlled during development. Several mechanisms acting on the mRNA level regulate when and where an mRNA is expressed. To explore the effects of conditional and transient gene expression in a developing organism, it is vital to experimentally enable abrogation and restoration of translation.
View Article and Find Full Text PDFNET Models Meeting 2024 white paper: the current state of neuroendocrine tumour research models and our future aspirations.
Endocr Oncol
January 2024
OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK.
Current models for the study of neuroendocrine tumours (NETs) are severely limited. While (e.g.
View Article and Find Full Text PDFBone dynamics in zebrafish on low- and high-frequency diets.
Comp Biochem Physiol B Biochem Mol Biol
January 2025
University of Akron, Department of Biology, Akron, OH, USA. Electronic address:
Article Synopsis
- Zebrafish were studied over 40 days to see how different diets (high vs. low frequency) affect bone health.
- Fish fed more frequently (3×/day) were larger in weight and length compared to those fed less often (2×/week).
- The frequent-feeding group had greater vertebral bone density but lower overall bone volume, while low-feeding fish had more signs of bone resorption in their scales.
- The researchers suggest that lower calorie intake might lead to higher leptin levels, which negatively impacts bone health in zebrafish.
miRNA-target complementarity in cnidarians resembles its counterpart in plants.
EMBO Rep
January 2025
Department of Ecology, Evolution and Behavior, Alexander Silberman Institute of Life Sciences, Faculty of Science, Hebrew University of Jerusalem, Jerusalem, 9190401, Israel.
microRNAs (miRNAs) are important post-transcriptional regulators that activate silencing mechanisms by annealing to mRNA transcripts. While plant miRNAs match their targets with nearly-full complementarity leading to mRNA cleavage, miRNAs in most animals require only a short sequence called 'seed' to inhibit target translation. Recent findings showed that miRNAs in cnidarians, early-branching metazoans, act similarly to plant miRNAs, by exhibiting full complementarity and target cleavage; however, it remained unknown if seed-based regulation was possible in cnidarians.
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