Introduction: Growth Differentiation Factor 15 (GDF15) is a mitochondrial-stress-responsive molecule whose expression strongly increases with aging and age-related diseases. However, its role in neurodegenerative diseases, including Alzheimer's disease (AD), is still debated.

Methods: We have characterized the expression of GDF15 in brain samples from AD patients and non-demented subjects (controls) of different ages.

Results: Although no difference in CSF levels of GDF15 was found between AD patients and controls, GDF15 was expressed in different brain areas and seems to be predominantly localized in neurons. The ratio between its mature and precursor form was higher in the frontal cortex of AD patients compared to age-matched controls ( < 0.05). Moreover, this ratio was even higher for centenarians ( < 0.01), indicating that aging also affects GDF15 expression and maturation. A lower expression of OXPHOS complexes I, III, and V in AD patients compared to controls was also noticed, and a positive correlation between and mRNA levels was observed. Finally, when GDF15 was silenced in dermal fibroblasts, a decrease in OXPHOS complexes transcript levels and an increase in levels were observed.

Discussion: Although GDF15 seems not to be a reliable CSF marker for AD, it is highly expressed in aging and AD brains, likely as a part of stress response aimed at counteracting mitochondrial dysfunction and neuroinflammation.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869280PMC
http://dx.doi.org/10.3389/fnagi.2022.1058665DOI Listing

Publication Analysis

Top Keywords

alzheimer's disease
8
gdf15
5
expression pattern
4
pattern gdf15
4
gdf15 human
4
human brain
4
brain changes
4
changes aging
4
aging alzheimer's
4
disease introduction
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!