AI Article Synopsis
- * The study found that while the patients had varying treatments, their clinical scores improved, but free Gly levels increased, indicating a potential relationship between Gly and stroke severity.
- * Notably, higher plasma Gly levels were linked to smaller infarct sizes, suggesting that Gly concentrations might serve as a valuable biomarker for assessing AIS.
Article Abstract
We developed a hollow fiber centrifugal ultrafiltration (HFCF-UF) method to study the change of plasma levels of free glycine (Gly) in patients with acute ischemic stroke (AIS). Twenty-four patients with AIS confirmed by diffusion-weighted imaging (DWI) were enrolled. During the study period, the patients did not receive any supplemental amino acids therapy that could affect the obtained results. Our results showed that although AIS patients adopted different methods of treatment (thrombolytic and non-thrombolytic), the clinical NIHSS score of AIS showed a downward trend whereas Gly concentration showed increased trend. Moreover, plasma free Gly concentration was positively correlated with ASPECTS score. The correlation between Gly levels and infarct volume showed a statistical significance. That is to say, higher Gly level predicted smaller infarct size. Thus, the change of free Gly level in plasma could be considered as a potential biomarker of AIS.
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| http://dx.doi.org/10.1007/s00726-023-03236-x | DOI Listing |
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