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Impact of HLA Alloimmunization in Gene-Modified Autologous Stem Cell Transplant For Transfusion-Dependent Thalassemia.
Blood
March 2025
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States.
We report our single center experience demonstrating that HLA Class I alloimmunization predicts longer time to platelet engraftment, increased bleeding complications and higher transfusion requirements in patients undergoing gene-modified hematopoietic stem cell transplant for transfusion-dependent beta thalassemia.
View Article and Find Full Text PDFSickle cell disease (SCD) and transfusion-dependent β-thalassemia (TDT) are inherited blood disorders caused by pathogenic variants of the β-globin gene. Historically, allogeneic hematopoietic stem cell transplantation (HSCT) from human leukocyte antigen (HLA)-matched donors has been the only curative option. However, as most patients with SCD or TDT lack HLA-matched donors, autologous or patient-derived HSCT can provide an alternative, transformative option.
View Article and Find Full Text PDFEffectiveness and safety of stellate ganglion block with trioxygen autologous blood retransfusion therapy for facial postherpetic neuralgia in elderly patients.
Sci Rep
March 2025
Department of Neurosurgery and Department of Neuroscience, Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
This study evaluated the efficacy and safety of stellate ganglion block (SGB) combined with trioxygen autologous blood retransfusion therapy (TABRT) in treating postherpetic neuralgia (PHN) of the head and face in elderly patients. A total of 190 patients (aged ≥ 60 years) with PHN were randomly assigned to receive either drug treatment alone (Group D, n = 40), drug treatment with SGB (Group DS, n = 52), drug treatment with TABRT (Group DT, n = 53), or drug combined SGB with TABRT (Group DST, n = 45). Key outcomes included pain visual analogue scale (VAS) scores and anxiety levels at baseline, 7 days, and 15 days post-treatment, the need for salvage analgesics, and complication rates assessed.
View Article and Find Full Text PDFApplication of autologous platelet rich plasma in Sun's procedure for acute type A aortic dissection under moderate hypothermia.
Front Cardiovasc Med
February 2025
Department of Cardiovascular Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, China.
Background: Coagulopathy and inflammatory response are the intractable complication during Sun's procedure for type A aortic dissection (AAD). This study aims to investigate the efficacy of autologous platelet rich plasma (aPRP) on the patients undergoing Sun's procedure under moderate hypothermia.
Methods: A total of 372 AAD patients who underwent Sun's procedure under moderate hypothermia were divided into aPRP group (aPRP was separated before heparinization and transfused after protamine neutralization) and Non-aPRP group (without aPRP apheresis).
Assessing angiographic results of saline autotransfusion and thrombus aspiration in STEMI patients.
Future Cardiol
March 2025
Department of Cardiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Background: Effective myocardial reperfusion in ST-Elevation Myocardial Infarction (STEMI) remains challenging despite advancements in primary percutaneous coronary intervention (PCI). This study evaluates the impact of thrombus aspiration (TA) and saline autotransfusion (SAT) compared to standard PCI (NOTA) on coronary flow dynamics and myocardial perfusion.
Research Design And Method: This prospective cohort study enrolled 157 STEMI patients who underwent primary PCI.
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