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Safety of Adjunctive Intraarterial Tenecteplase Following Mechanical Thrombectomy: The ALLY Pilot Trial.
Stroke
January 2025
Department of Neurology, University of Toledo, OH (S.F.Z., A.C.C., R.E.B., H.S.A., K.G., R.R., M.A.J.).
Background: Recent studies suggest that the use of adjunctive intraarterial alteplase after mechanical thrombectomy (MT) may improve outcomes; however, there are limited data on the use of intraarterial tenecteplase, a newer-generation lytic, in this acute ischemic stroke patient population. Here, we evaluate the use of intraarterial tenecteplase in the ALLY pilot study (Adjunctive Intraarterial Tenecteplase Following Mechanical Thrombectomy).
Methods: ALLY was a prospective, single-center, nonrandomized pilot study assessing the feasibility and safety of intraarterial tenecteplase up to 4.
Advances in Atrial Fibrillation Management: A Guide for General Internists.
J Clin Med
December 2024
Department of Medicine, University of Arizona, Tucson, AZ 85719, USA.
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, impacting approximately 6.1 million adults in the United States, with projections to increase two-fold by 2030. AF significantly increases the risk of stroke and other adverse cardiovascular events, leading to increased morbidity and mortality.
View Article and Find Full Text PDFFerulic Acid Relieves the Oxidative Stress Induced by Oxidized Fish Oil in Oriental River Prawn () with an Emphasis on Lipid Metabolism and Gut Microbiota.
Antioxidants (Basel)
November 2024
Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China.
To investigate the potential of ferulic acid (FA) in attenuating the deleterious effects of oxidized fish oil (OF) on , four experimental diets were formulated: 3% fresh fish oil (CT group, peroxide value: 2.2 mmol/kg), 3% oxidized fish oil (OF group, peroxide value: 318 mmol/kg), and 3% OF with an additional 160 and 320 mg/kg of FA (OF+FA160 group and OF+FA320 group, respectively). (initial weight: 0.
View Article and Find Full Text PDFNIR Light-Triggered Structural Modulation of Self-Assembled Prion Protein Aggregates.
Small
January 2025
Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 335 Science Road, Daejeon, 34141, Republic of Korea.
The self-replication of misfolded prion protein (PrP) aggregates is the major pathological event of different prion diseases, affecting mammal brains by cross-species transmission. Here, the structural modulation of PrP aggregates are reported by activated carbon materials upon near-infrared (NIR) light irradiation. Activated carbon cobalt (ACC) nanosheets are synthesized using glycerol and metal salts to utilize the charge carriers released under NIR light exposure.
View Article and Find Full Text PDFIdentification, Biocontrol and Plant Growth Promotion Potential of Endophytic Streptomyces sp. a13.
Curr Microbiol
January 2025
Microbial Biotechnology Laboratory, Life Sciences Division, Institute of Advanced Study in Science and Technology, Guwahati, Assam, 781035, India.
Medicinal plants often harbour various endophytic actinomycetia, which are well known for their potent antimicrobial properties and plant growth-promoting traits. In this study, we isolated an endophytic actinomycetia, A13, from the leaves of tea clone P312 from the MEG Tea Estate, Meghalaya, India. The isolate A13 was identified as Streptomyces sp.
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