AI Article Synopsis
- In eukaryotic cells, the process of generating mature mRNA involves cleavage and polyadenylation (CPA) at the 3' end of transcripts.
- Many transcripts undergo alternative polyadenylation (APA), creating different mRNA forms that can affect protein coding sequences or alter the length of the 3' untranslated regions (3'UTR).
- Recent studies introduce a new mechanism called sequential APA, which offers fresh insights into how various regulatory processes control these different mRNA isoforms.
Article Abstract
In eukaryotic cells, a key RNA processing step to generate mature mRNA is the coupled reaction for cleavage and polyadenylation (CPA) at the 3' end of individual transcripts. Many transcripts are alternatively polyadenylated (APA) to produce mRNAs with different 3' ends that may either alter protein coding sequence (CDS-APA) or create different lengths of 3'UTR (tandem-APA). As the CPA reaction is intimately associated with transcriptional termination, it has been widely assumed that APA is regulated cotranscriptionally. Isoforms terminated at different regions may have distinct RNA stability under different conditions, thus altering the ratio of APA isoforms. Such differential impacts on different isoforms have been considered as post-transcriptional APA, but strictly speaking, this can only be considered "apparent" APA, as the choice is not made during the CPA reaction. Interestingly, a recent study reveals sequential APA as a new mechanism for post-transcriptional APA. This minireview will focus on this new mechanism to provide insights into various documented regulatory paradigms.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880608 | PMC |
| http://dx.doi.org/10.14348/molcells.2023.2176 | DOI Listing |
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