AI Article Synopsis
- A clinical strain of Klebsiella pneumoniae, identified as sequence type 307, was found to have three different alleles of the flu gene, which is linked to the E. coli virulence factor antigen 43 that aids in biofilm formation.
- These alleles are integrated into the bacterial chromosome within putative integrative conjugative elements, suggesting a possible means of genetic transfer.
- The strain shows specific traits like unique colony morphology and increased biofilm production, but produces a low amount of a capsule that may influence the function of Ag43; globally, about 3.7% of Klebsiella pneumoniae strains possess one or two flu alleles.
Article Abstract
A clinical strain of Klebsiella pneumoniae typed as sequence type 307 carrying three different alleles of the flu gene encoding the Escherichia coli virulence factor antigen 43 associated with biofilm formation was detected and characterized. The flu alleles are located in the chromosome inside putative integrative conjugative elements. The strain displays the phenotypes associated with Ag43, i.e. bi-phasic colony morphology and enhanced biofilm production. Furthermore, the strain produces low amount of capsule known to affect Ag43 function. Analysis of 1431 worldwide deposited genomes revealed that 3.7% Klebsiella pneumoniae carry one or two flu alleles.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899198 | PMC |
| http://dx.doi.org/10.1007/s10096-023-04552-6 | DOI Listing |
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