AI Article Synopsis
- Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, emerged in December 2019 and has led to a worldwide pandemic due to its rapid spread and evolving variants.
- A comprehensive review examined the characteristics of concerning SARS-CoV-2 variants, focusing on how these mutations affect the effectiveness of current vaccines and treatments.
- The findings indicate that certain variants can evade vaccine-induced immunity and neutralizing antibodies, suggesting the need for updated strategies in vaccination and therapeutic approaches as the pandemic continues.
Article Abstract
Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) initially emerged in December 2019 and has subsequently expanded globally, leading to the ongoing pandemic. The extensive spread of various SARS-CoV-2 variants possesses a serious public health threat. An extensive literature search along with deep analysis was performed to describe and evaluate the characteristics of SARS-CoV-2 variants of concern in relation to the effectiveness of the current vaccines and therapeutics. The obtained results showed that several significant mutations have evolved during the COVID-19 pandemic. The developed variants and their various structural mutations can compromise the effectiveness of several vaccines, escape the neutralizing antibodies, and limit the efficiency of available therapeutics. Furthermore, deep analysis of the available data enables the prediction of the future impact of virus mutations on the ongoing pandemic along with the selection of appropriate vaccines and therapeutics.
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| http://dx.doi.org/10.1089/vim.2022.0122 | DOI Listing |
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