AI Article Synopsis
- * Traditional desensitization methods for these patients often have limitations, making it difficult to find suitable donors.
- * The presented case is the first successful use of imlifidase for a highly sensitized lung transplant candidate, leading to a successful bilateral lung transplant.
Article Abstract
Lung transplant candidates who are highly sensitized against human leucocyte antigen present an ongoing challenge with regards to finding immunologically acceptable donors. Desensitization strategies aimed at reducing preformed donor-specific antibodies have a number of limitations. Imlifidase, an IgG-degrading enzyme derived from Streptococcus pyogenes, is a novel agent that has been used to convert positive crossmatches to negative in kidney transplant candidates, allowing transplantation to occur. We present the first case of imlifidase use for antibody depletion in a highly sensitized lung transplant candidate who went on to undergo a successful bilateral lung transplant.
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| http://dx.doi.org/10.1016/j.ajt.2022.11.025 | DOI Listing |
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