Ceftriaxone-resistant, multidrug-resistant with a novel mosaic gene, France, June 2022.

We report a ceftriaxone-resistant, multidrug-resistant urogenital gonorrhoea case in a heterosexual woman in France, June 2022. The woman was successfully treated with azithromycin 2 g. She had unprotected sex with her regular partner, who developed urethritis following travel to Vietnam and Switzerland. Whole genome sequencing of the gonococcal isolate (F92) identified MLST ST1901, NG-STAR CC-199, and the novel mosaic , which caused ceftriaxone resistance. is 98.7% identical to , reported in various ceftriaxone-resistant strains, including the internationally spreading FC428 clone.