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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698277 | PMC |
| http://dx.doi.org/10.4103/singaporemedj.SMJ-2021-005 | DOI Listing |
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Pediatric Mycosis Fungoides Mimicking Benign Dermatoses: A Report of a Rare Case.
Am J Case Rep
January 2025
Department of Pathology, Hospital Selayang, Batu Caves, Selangor, Malaysia.
BACKGROUND Primary cutaneous lymphomas (PCL) are a multifaceted spectrum of cutaneous T cell lymphoma (CTCL) and cutaneous B cell lymphomas (CBCL). Mycosis fungoides (MF) is a rare subset of CTCL that primarily affects adults, and its occurrence in children is exceedingly rare. Most pediatric MF manifests as hypopigmented patches resembling other benign dermatoses, causing diagnostic challenges.
View Article and Find Full Text PDFBiomedical applications of tyrosinases and tyrosinase inhibitors.
Enzymes
September 2024
Neurofarba Department, Pharmaceutical and Nutraceutical Section, University of Florence, Sesto Fiorentino, Florence, Italy. Electronic address:
Article Synopsis
- Tyrosinase is linked to various skin conditions, including both hypopigmentation disorders like vitiligo and hyperpigmentation disorders like melasma, and is also implicated in melanoma progression.
- Current treatments for hyperpigmentation include hydroquinone, azelaic acid, and tretinoin, while new tyrosinase inhibitors are being researched for potential anti-melanoma effects.
- Kojic acid and vitamin C are commonly used in cosmetics to prevent food browning, and bacterial enzymes show promise in biomedical applications, including the production of L-DOPA, a medication for Parkinson’s disease.
Evaluation of diagnostic accuracy of dermoscopy in some common hypopigmented skin diseases.
Arch Dermatol Res
August 2024
Department of Dermatology and Venereology, Faculty of Medicine, Tanta University Hospital, 31527, Al-Bahr St., Tanta, Egypt.
Article Synopsis
- Diagnosis of cutaneous hypopigmentation can be challenging, but dermoscopy shows promise in distinguishing between various conditions like vitiligo and pityriasis alba.
- The study evaluated 168 patients to identify dermoscopic features unique to different hypopigmented conditions and assessed their diagnostic accuracy.
- Key findings included that certain patterns like starburst and micro-koebnerization are specific to vitiligo, while other conditions exhibited different patterns; overall, dermoscopy was most effective for conditions such as nevus depigmentosus and pityriasis alba, showing high sensitivity rates.
Article Synopsis
- When evaluating pediatric patients of color, healthcare providers must recognize unique dermatologic conditions that are more prevalent, such as keloids and postinflammatory hyperpigmentation.* -
- Conditions like vitiligo can significantly impact quality of life and may be harder to identify in darker skin due to inflammation being less visible.* -
- Treatment approaches should take into account cultural norms and lifestyle factors, including preferences for sunscreen and hair care practices, to ensure effective care.*
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