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Expensive Drugs for Rare Diseases in Canada: What Value and at What Cost? | LitMetric

Expensive Drugs for Rare Diseases in Canada: What Value and at What Cost?

Healthc Pap

Chair, British Columbia Expensive Drugs for Rare Diseases Advisory Committee, Provincial Health Services Authority, Victoria, BC.

Published: January 2023

AI Article Synopsis

Article Abstract

There has been explosive growth in the market for expensive drugs for rare diseases (EDRDs). Traditional standards of evidence are not achievable for rare diseases, so lower standards are applied. The price of these drugs is extremely high. This combination of lower standards and higher prices make EDRDs attractive to manufacturers. Legislation designed to incentivize drug development for rare diseases contains loopholes that drive prices up worldwide. Canada compounds those problems with a complex network of agencies that impede communication between those providing market authorization and those purchasing drugs. Drug pricing is not related to metrics like investment or value, but rather willingness to pay. Without high-quality evidence to assess value, we inadvertently prioritize patients with rare diseases over those with common diseases, creating conflict among ethical principles such as social utility, justice and the rule of rescue. Lack of transparency over what is being funded and for whom makes it hard to mitigate challenges through effective policy development. We review the evidentiary, economic and ethical issues around EDRDs and ways to move forward, including enhanced transparency and the development of high-quality evidence to ensure that we do not pay for drugs that do not work.

Download full-text PDF

Source
http://dx.doi.org/10.12927/hcpap.2023.27000DOI Listing

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