Nocardia neocaledoniensis is a rare species of Nocardia bacteria, identified in 2004 in hypermagnesian ultramafic soil of New Caledonia. Culture of this opportunistic pathogen from spinal biopsy samples confirmed N. neocaledoniensis spondylodiscitis in an immunocompromised man. Isolation of this unusual species from spinal biopsy samples illustrates its underappreciated ability to cause invasive infection.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881783PMC
http://dx.doi.org/10.3201/eid2902.221389DOI Listing

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Article Synopsis
  • - N. neocaledoniensis is a rare pathogen that primarily affects people with weakened immune systems, leading to infections like skin abscesses.
  • - The case report details how mNGS (metagenomic next-generation sequencing) was used to successfully diagnose this infection, highlighting its role in identifying hard-to-culture pathogens.
  • - This report serves as a valuable resource for understanding and treating N. neocaledoniensis infections in clinical settings.
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  • - The study investigated the antimicrobial resistance and genetic factors of 138 clinical strains of Nocardia species, revealing a variety of species with differing resistance profiles.
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Nocardia neocaledoniensis is a rare species of Nocardia bacteria, identified in 2004 in hypermagnesian ultramafic soil of New Caledonia. Culture of this opportunistic pathogen from spinal biopsy samples confirmed N. neocaledoniensis spondylodiscitis in an immunocompromised man.

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Recent advancements in DNA-based approaches have led to the identification of uncommon and rare bacterial pathogens. In this study, by utilizing a DNA-based approach, a total of 1043 clinical specimens were processed for the identification of actinobacteria targeting the 16S rRNA and gyrB genes. Drug susceptibility testing was also conducted using micro-broth dilution and PCR.

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