Background: and are biologically potential genes responsible for prostate cancer.
Aim: We aimed to analyse the expression and association of and genes in prostate cancer.
Subjects And Methods: Web-based bioinformatics tools were used to assess the association of and genes with prostate cancer risks. A case-control study of 210 prostate cancer cases and 207 controls was also approved to determine the allelic variants of the gene- rs2740574 () and the variant of gene-rs776746 () using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). The risk of prostate cancer was estimated as odds ratio (OR) and 95% confidence interval (CI) using unrestricted logistic regression models.
Results: Our data confirmed that both and genes are significantly associated with higher prostate cancer risks. In the case of polymorphism, the heterozygote (*1 A/*1B), mutant (*1B/*1B), and combined heterozygote plus mutant (*1A/*1B+*1B/*1B) genotypes showed 3.52-fold, 3.90-fold, and 3.67-fold increased risk of prostate cancer, respectively. In the case of polymorphism, the heterozygote (*1/*3), mutant (*3/*3), and combined (*1/*3+*3/*3) genotypes were found to be significantly associated with 5.11-, 5.49-, and 5.28-fold greater risk of prostate cancer, respectively.
Conclusion: Our results indicate that and are significantly associated with increased prostate cancer risk.KEY MESSAGESBioinformatics tools were used and concluded that the and genes were significantly associated with the development and progression of prostate cancer. and polymorphisms were significantly associated with an increased risk of prostate cancer.Polymerase Chain Reaction (PCR)-Restriction Fragment Length Polymorphism (RFLP) was used to estimate polymorphisms of prostate cancer progression in the Bangladeshi population.
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