For the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, clinical manifestations are broad and highly heterogeneous for both sexes. We aimed to determine how biological sex and age impact immune gene expression, particularly influencing the humoral neutralizing antibody (NAb) response and the cytokine production in coronavirus disease 2019 (COVID-19) subjects. The immune gene expression, according to biological sex and age, was assessed using the genome wide expression profile of blood proteins from healthy individuals using the Genotype Tissue Expression (GTEx) database. Moreover, anti-SARS-CoV-2 neutralizing antibody titers and cytokine levels were determined in blood samples from 141 COVID-19 individuals from Medellín, Colombia. Among subjects with COVID-19, males had statistically significantly higher median NAb titers and serum concentrations of interleukin-6 and CC chemokine ligand 3 than females. Overall, our findings point out a more robust innate immune response in women that could help recognize and restrain the virus faster than in men.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9847338 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2023.e13045 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Responses of biological characteristics and detoxification enzymes in the fall armyworm to methoxyfenozide stress.
J Econ Entomol
January 2025
Hubei Engineering Technology Center of Forewarning and Management of Agricultural and Forestry Pests, Yangtze University, Jingzhou 434000, PR China.
Methoxyfenozide is an insecticide with a unique mode of action on the insect ecdysone receptor and has been registered for the control of insect pests all over the world. In the present work, Spodoptera frugiperda was exposed to sublethal and lethal concentrations of methoxyfenozide to determine its impact on specific biological traits, metabolic enzyme activity, and the expression of detoxification enzymes. The result showed that 72-h posttreatment with LC50 and LC70 of methoxyfenozide significantly reduced the fecundity (eggs/female) of the F0 generation compared to those of the control group.
View Article and Find Full Text PDFAttitudes of future teachers toward death education: An analysis of the impact of multiple factors.
Death Stud
January 2025
Department of Pedagogy, University of Córdoba, Córdoba, Spain.
The aim of this research is to analyze the attitude of future teachers toward death education and which are the factors that influence their predisposition about it. For this, a quantitative study with a descriptive-inferential cross-sectional design was carried out with a sample composed of 204 Primary Education Degree students from the University of Malaga. The Death Education Attitudes Scale-Teachers was implemented as a validated instrument, in which biological, emotional, identity, contextual, formative and motivational factors were considered within the attitude's incidence.
View Article and Find Full Text PDFEffects of 8 Weeks of Moderate- or High-Volume Strength Training on Sarcoplasmic Reticulum Ca Handling in Elite Female and Male Rowers.
Scand J Med Sci Sports
January 2025
Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
While acute exercise affects sarcoplasmic reticulum (SR) function, the impact of resistance training remains unclear. The purpose of the present study was to investigate SR Ca handling plasticity in response to moderate- and high-volume strength training in elite rowers. Twenty elite male (n = 12) and female (n = 8) rowers performed three weekly strength training sessions for 8 weeks and were randomly allocated to either perform 3 sets (3-SET) or progressive increase from 5 to 10 sets (10-SET) of 10 repetitions during the training period.
View Article and Find Full Text PDFFactors associated with shisha smoking: Results from a cross-sectional telephone-based survey among the general population adults in Nigeria.
Tob Prev Cessat
January 2025
Department of Psychiatry, Faculty of Clinical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Introduction: In Nigeria, there is very limited evidence on factors that influence shisha smoking, and this hinders effective tobacco control policymaking. We, therefore, aimed to identify factors associated with shisha smoking among the general population adults in Nigeria.
Methods: We conducted a telephone-based, cross-sectional survey between 28 July and 11 September 2022 in 12 states of Nigeria.
Charles Bonnet syndrome in patients with geographic atrophy secondary to age-related macular degeneration: a cross-sectional study.
Ther Adv Ophthalmol
January 2025
Department of Ophthalmology, Zealand University Hospital, Roskilde, Denmark.
Background: Age-related macular degeneration (AMD) is a prevalent cause of irreversible vision loss among the elderly. The prevalence and detailed characteristics of Charles Bonnet syndrome (CBS) remain largely unexplored in patients with geographic atrophy (GA) secondary to AMD.
Objectives: To investigate the prevalence and characteristics of CBS in patients with GA secondary to AMD.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!