Purpose: Creating enough decompression, favorable outcome, less complication, and maintain adequate lordosis and stability in the patients with cervical myelopathy due to multilevel massive ossification of the posterior longitudinal ligament (OPLL) still poses a challenge for surgeons. The aim of our study is to retrospectively evaluate our patients and try to seek a better surgical strategy.
Methods: Between 2015 and 2019, 55 consecutive patients with multilevel massive OPLL underwent surgical treatment. Among these, 40 patients were treated with cervical laminectomy and then anterior decompression, fusion, and fixation (ADF), which was defined as group 1, and 15 patients were treated with cervical laminectomy and fixation simultaneously, which was defined as group 2. The patient's radiographic characteristics and postoperative outcomes were evaluated.
Results: Better postoperative cervical sagittal lordosis and less long-term axial pain was achieved in group 1 ( < 0.001), though the functional outcome had no significant difference. In the multivariable analysis, anterior fixation accounts for independent factors for better cervical sagittal alignment ( < 0.001). No complications directly associated with cervical laminectomy were observed.
Conclusion: In patients with cervical multilevel massive OPLL, laminectomy at compression level and then ADF depended on the severity and range of compression, but corpectomy of not more than two vertebral bodies is suggested, except K-line (+) and long-segment massive OPLL majorly involving the C2 and posterior laminectomy above and below the OPLL-affected levels with posterior fixation simultaneously.
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http://dx.doi.org/10.3389/fsurg.2022.1066120 | DOI Listing |
Alzheimers Dement
December 2024
Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, TAS, Australia.
Background: People living in diverse rural areas have shown higher rates of Alzheimer's disease and related dementias (ADRD) compared with their urban counterparts. Further, individuals in rural areas have higher rates of modifiable risk factors for ADRD, such as physical inactivity and alcohol misuse, that account for up to 40% of dementia cases. This study aimed to investigate the efficacy of a novel public health initiative to reduce dementia incidence in both urban and rural settings in Australia's island state: Tasmania.
View Article and Find Full Text PDFBMC Public Health
December 2024
Social and Behavioural Health Sciences Division & Centre for Global Health, Dalla Lana School of Public Health, University of Toronto, Ontario, Canada.
Background: Since COVID-19 emerged in 2020, the promotion of health equity, including in research, has further been challenged worldwide by both global health governance (GHG) processes and decisions, and national public health control measures. These global and national decisions have also led to the 'covidization' of health research agendas where resources have been massively channelled to address COVID-19, especially during the first years of the pandemic. This situation could potentially result in current and future population health research priorities not explicitly tackling equity as a central tenet.
View Article and Find Full Text PDFJMIR Mhealth Uhealth
October 2024
Department of Endocrinology, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region, Chengdu, China.
Background: Obesity is a rapidly increasing health problem in China, causing massive economic and health losses annually. Many techniques have emerged to help people with obesity better adhere to intervention programs and achieve their weight loss goals, including food replacement and internet-delivered weight loss consultations. Most studies on weight loss interventions mainly focused on the change in body weight or BMI; however, body fat, especially visceral fat mass, is considered the main pathogenic factor in obesity.
View Article and Find Full Text PDFCurr Med Sci
October 2024
Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, 310015, China.
Alzheimer's disease (AD) is one of the most common forms of neurodegenerative dementia. The etiology of AD is multifactorial, and its complex pathophysiology involves tau and amyloid-β deposition, increased oxidative stress, neuroinflammation, metabolic disorders, and massive neuronal loss. Due to its complex pathology, no effective cure for AD has been found to date.
View Article and Find Full Text PDFACS Appl Mater Interfaces
October 2024
School of Integrated Circuits, Hubei Key Laboratory for Advanced Memories, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China.
In the era of big data, the amount of global data is increasing exponentially, and the storage and processing of massive data put forward higher requirements for memory. To deal with this challenge, high-density memory and neuromorphic computing have been widely investigated. Here, a gradient-doped multilayer phase-change memory with two-level states, four-level states, and linear conductance evolution using different pulse operations is proposed.
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