AI Article Synopsis
- Bacteraemia (SAB) is a significant cause of both bacteraemia and infectious endocarditis (IE), with about 5-12% of SAB patients developing IE, particularly in adults with skin issues like epidermolytic hyperkeratosis (EHK).
- A 43-year-old male presented with fever and skin diseases, later diagnosed with EHK following genetic tests, which contributed to his SAB and IE.
- The combination of a compromised skin barrier due to EHK and poor sanitation led to bacterial infections; hence, it's crucial to diagnose and treat EHK early to prevent serious complications like IE and organ abscesses.
Article Abstract
Background: bacteraemia (SAB) is among the leading causes of bacteraemia and infectious endocarditis. The frequency of infectious endocarditis (IE) among SAB patients ranges from 5% to 10%-12%. In adults, the characteristics of epidermolytic hyperkeratosis (EHK) include hyperkeratosis, erosions, and blisters. Patients with inflammatory skin diseases and some diseases involving the epidermis tend to exhibit a disturbed skin barrier and tend to have poor cell-mediated immunity.
Case Summary: We describe a case of SAB and infective endocarditis in a 43-year-old male who presented with fever of unknown origin and skin diseases. After genetic tests, the skin disease was diagnosed as EHK.
Conclusion: A breached skin barrier secondary to EHK, coupled with inadequate sanitation, likely provided the opportunity for bacterial seeding, leading to IE and deep-seated abscess or organ abscess. EHK may be associated with skin infection and multiple risk factors for extracutaneous infections. Patients with EHK should be treated early to minimize their consequences. If patients with EHK present with prolonged fever of unknown origin, IE and organ abscesses should be ruled out, including metastatic spreads.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9850991 | PMC |
| http://dx.doi.org/10.12998/wjcc.v10.i36.13418 | DOI Listing |
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