AI Article Synopsis
- Parkinson's disease (PD) is a complex condition influenced by various factors, with research suggesting that T cells significantly impact its development.
- By analyzing the RNA expression of activated CD4+ T cells from patients at different PD stages, researchers observed distinct changes in gene expression over time and identified key pathways affected, particularly the IL-17 pathway.
- Findings showed an increase in Th17 cells and a unique subtype of IL-17 producing γδ-T cells, indicating their potential novel role in the disease's progression.
Article Abstract
Parkinson's disease (PD) emerges as a complex, multifactorial disease. While there is increasing evidence that dysregulated T cells play a central role in PD pathogenesis, elucidation of the pathomechanical changes in related signaling is still in its beginnings. We employed time-resolved RNA expression upon the activation of peripheral CD4+ T cells to track and functionally relate changes on cellular signaling in representative cases of patients at different stages of PD. While only few miRNAs showed time-course related expression changes in PD, we identified groups of genes with significantly altered expression for each different time window. Towards a further understanding of the functional consequences, we highlighted pathways with decreased or increased activity in PD, including the most prominent altered IL-17 pathway. Flow cytometric analyses showed not only an increased prevalence of Th17 cells but also a specific subtype of IL-17 producing γδ-T cells, indicating a previously unknown role in PD pathogenesis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867723 | PMC |
| http://dx.doi.org/10.1038/s41420-023-01333-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!