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Clinical practice guidelines for antimicrobial-loaded cements and beads in orthopedic trauma and arthroplasty.
Eur J Orthop Surg Traumatol
November 2024
Department of Orthopedics, University of Colorado Anschutz Medical Campus, 12631 E. 17th Avenue, Mail Stop B202, Aurora, CO, 80045, USA.
Purpose: Implants in orthopedic trauma and arthroplasty surgery establish a milieu conducive to biofilm formation. Antimicrobial-loaded cements (ABCs) and beads have become popular in treating acute and chronic orthopedic surgery-related infections. The growing incidence of antimicrobial resistance has necessitated the exploration of alternative antibiotic medications.
View Article and Find Full Text PDFAntimicrobial-loaded bone cement use is highly variable in joint replacement surgery: a survey of Australian arthroplasty surgeons.
ANZ J Surg
June 2023
Centre of Orthopaedic and Trauma Research, University of Adelaide, Adelaide, South Australia, Australia.
Antimicrobial strategies for scaffolds aided periodontal regeneration - road so far. A systematic review.
J Pak Med Assoc
May 2022
Department of Dental Materials, Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan.
Objective: To give a comprehensive understanding of the efficacy of antimicrobial-loaded scaffolds as drug delivery system for periodontal regeneration, and to review the recent advances in the field of periodontal regeneration.
Methods: The literature was reviewed using key words "antimicrobial releasing periodontal scaffolds" on Science Direct, PubMed and Web of Science search engines. Shortlisted articles were evaluated on the basis of specific inclusion-exclusion criteria.
Simulated large joint fluid model for evaluating intra-articular antibiotic delivery systems: initial evaluation using antibiotic-loaded calcium sulfate beads.
J Bone Jt Infect
May 2022
Austin Medical Ventures, Germantown, 38138, USA.
: Local antimicrobial delivery via calcium sulfate (CaSO ) beads is used as an adjunctive treatment for periprosthetic joint infection. There is limited clinical information describing the performance of antimicrobial-loaded CaSO (ALCS) in large-scale applications. We developed a simulated large joint model to study properties of eluting ALCS.
View Article and Find Full Text PDFAdaptive antimicrobial resistance, a description of microbial variants, and their relevance to periprosthetic joint infection.
Bone Joint J
May 2022
Department of Orthopaedic Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Periprosthetic joint infection (PJI) is a difficult complication requiring a comprehensive eradication protocol. Cure rates have essentially stalled in the last two decades, using methods of antimicrobial cement joint spacers and parenteral antimicrobial agents. Functional spacers with higher-dose antimicrobial-loaded cement and antimicrobial-loaded calcium sulphate beads have emphasized local antimicrobial delivery on the premise that high-dose local antimicrobial delivery will enhance eradication.
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