AI Article Synopsis
- PEG-coated PLGA nanoparticles are effective for targeted cancer treatment due to their biocompatibility and ability to accumulate in tumors via the EPR effect.
- Doxorubicin's efficacy is limited by its cardiotoxicity, and the study explores the use of hyaluronic acid to enhance drug delivery and reduce metastasis in breast cancer models.
- Treatment with HA-PEG-PLGA nanoparticles significantly inhibited tumor growth and metastasis compared to controls and free doxorubicin, indicating potential for further clinical development after more safety studies.
Article Abstract
Polyethylene glycol (PEG) coated Poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) for cancer treatment are biocompatible, nonimmunogenic and accumulate in tumour sites due to the enhanced permeability and retention (EPR). Doxorubicin (DOX) is a potent but cardiotoxic anticancer agent. Hyaluronic acid (HA) occurs naturally in the extra-cellar matrix and binds to CD44 receptors which are overexpressed in cancer metastasis, proven to be characteristic of cancer stem cells and responsible for multidrug resistance. In this study, an athymic mice model of breast cancer metastasis was developed using red fluorescent protein (RFP)-labelled triple negative cancer cells. The animals were divided into four treatment groups (Control, HA-PEG-PLGA nanoparticles, PEG-PLGA nanoparticles, and Free DOX). The tumour size growth was assessed until day 25 when animals were sacrificed. Mice treated with HA-PEG-PLGA NPs inhibited tumour growth. The tumour growth at day 25 (118% ± 13.0) was significantly (p < 0.05) less than PEG-PLGA NPs (376% ± 590 and control (826% ± 970). Fluorescent microscopy revealed that HA-PEG-PLGA NPs had significantly (p < 0.05) less metastasis in liver, spleen, colon, and lungs as compared to control and to Free DOX groups. The efficacy of HA-PEG-PLGA NPs was proven in vivo. Further pharmacokinetic and toxicity studies are required for this formulation to be ready for clinical research.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863707 | PMC |
| http://dx.doi.org/10.3390/polym15020284 | DOI Listing |
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