AI Article Synopsis
- Nature has developed unique materials that are biocompatible and can be used as biomimetic materials, like silica particles derived from marine diatom proteins.
- Researchers used the R5 and RRIL peptides to create silica particles that can effectively deliver vaccine antigens.
- These engineered silica particles not only enhance the effectiveness of vaccines but also trigger immune responses, such as NETosis in human neutrophils and cytokine secretion in mouse dendritic cells.
Article Abstract
Nature offers a wide range of evolutionary optimized materials that combine unique properties with intrinsic biocompatibility and that can be exploited as biomimetic materials. The R5 and RRIL peptides employed here are derived from silaffin proteins that play a crucial role in the biomineralization of marine diatom silica shells and are also able to form silica materials in vitro. Here, we demonstrate the application of biomimetic silica particles as a vaccine delivery and adjuvant platform by linking the precipitating peptides R5 and the RRIL motif to a variety of peptide antigens. The resulting antigen-loaded silica particles combine the advantages of biomaterial-based vaccines with the proven intracellular uptake of silica particles. These particles induce NETosis in human neutrophils as well as IL-6 and TNF-α secretion in murine bone marrow-derived dendritic cells.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866965 | PMC |
| http://dx.doi.org/10.3390/pharmaceutics15010121 | DOI Listing |
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