AI Article Synopsis
- - The clinical use of -nitrosoglutathione (GSNO) as a potential therapy is hindered by its instability, prompting the development of various formulations to protect it from degradation.
- - Key challenges in these formulations include achieving low encapsulation efficiency and managing burst release, primarily due to GSNO's high water solubility and small molecular size.
- - The review focuses on different nano/micro-formulation strategies for GSNO delivery systems, offering insights for future researchers on effective encapsulation techniques.
Article Abstract
As a potential therapeutic agent, the clinical application of -nitrosoglutathione (GSNO) is limited because of its instability. Therefore, different formulations have been developed to protect GSNO from degradation, delivery and the release of GSNO at a physiological concentration in the active position. Due to the high water-solubility and small molecular-size of GSNO, the biggest challenges in the encapsulation step are low encapsulation efficiency and burst release. This review summarizes the different nano/micro-formulation strategies of a GSNO related delivery system to provide references for subsequent researchers interested in GSNO encapsulation.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863240 | PMC |
| http://dx.doi.org/10.3390/nano13020224 | DOI Listing |
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