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Structure and Formation of Z-DNA and Z-RNA. | LitMetric

Structure and Formation of Z-DNA and Z-RNA.

Molecules

Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Published: January 2023

AI Article Synopsis

Article Abstract

Despite structural differences between the right-handed conformations of A-RNA and B-DNA, both nucleic acids adopt very similar, left-handed Z-conformations. In contrast to their structural similarities and sequence preferences, RNA and DNA exhibit differences in their ability to adopt the Z-conformation regarding their hydration shells, the chemical modifications that promote the Z-conformation, and the structure of junctions connecting them to right-handed segments. In this review, we highlight the structural and chemical properties of both Z-DNA and Z-RNA and delve into the potential factors that contribute to both their similarities and differences. While Z-DNA has been extensively studied, there is a gap of knowledge when it comes to Z-RNA. Where such information is lacking, we try and extend the principles of Z-DNA stability and formation to Z-RNA, considering the inherent differences of the nucleic acids.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867160PMC
http://dx.doi.org/10.3390/molecules28020843DOI Listing

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