AI Article Synopsis
- The study analyzed the effects of co-infection with SARS-CoV-2 and other viruses (HAdV-5 or IAV) in lab settings, both in vitro and in vivo.
- During co-infection, HAdV-5 did not hinder the replication of SARS-CoV-2, showing similar viral levels in lungs of infected hamsters.
- Co-infected animals showed more severe illness and lung damage compared to those infected with SARS-CoV-2 alone, indicating that mixed infections can lead to heightened disease severity.
Article Abstract
In this study, we investigated the features of the infectious process by simulating co-infection with SARS-CoV-2 and human adenovirus type 5 (HAdV-5) or influenza A virus (IAV) in vitro and in vivo. The determination of infectious activity of viruses and digital PCR demonstrated that during simultaneous and sequential HAdV-5 followed by SARS-CoV-2 infection in vitro and in vivo, the HAdV-5 infection does not interfere with replication of SARS-CoV-2. The hamsters co-infected and mono-infected with SARS-CoV-2 exhibited nearly identical viral titers and viral loads of SARS-CoV-2 in the lungs. The hamsters and ferrets co-infected by SARS-CoV-2- and IAV demonstrated more pronounced clinical manifestations than mono-infected animals. Additionally, the lung histological data illustrate that HAdV-5 or IAV and SARS-CoV-2 co-infection induces more severe pathological changes in the lungs than mono-infection. The expression of several genes specific to interferon and cytokine signaling pathways in the lungs of co-infected hamsters was more upregulated compared to single infected with SARS-CoV-2 animals. Thus, co-infection with HAdV-5 or IAV and SARS-CoV-2 leads to more severe pulmonary disease in animals.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860643 | PMC |
| http://dx.doi.org/10.3390/microorganisms11010180 | DOI Listing |
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