AI Article Synopsis

  • Tocilizumab is a bDMARD that targets the IL-6 pathway, commonly used to treat rheumatoid arthritis, which can lead to serious joint damage.
  • A study investigated the relationship between specific genetic variations (SNPs) in a particular gene and the risk of adverse effects from tocilizumab in 88 RA patients.
  • The research identified links between certain SNPs and specific side effects, suggesting that these genetic markers could be useful in predicting the toxicity of tocilizumab in RA patients.

Article Abstract

Tocilizumab is a first-line biologic disease-modifying anti-rheumatic drug (bDMARD) that inhibits the interleukin-6 (IL-6) pathway by antagonizing the IL-6 receptor (IL-6R). Tocilizumab is widely used to treat rheumatoid arthritis (RA), a prevalent autoimmune disease that can cause irreversible joint damage and disability. Although many bDMARDs have been developed for RA, there is a lack of validated biomarkers which could guide personalized medicine strategies. To evaluate whether single-nucleotide polymorphisms (SNPs) in the gene could predict tocilizumab toxicity in patients with RA, we conducted a retrospective cohort study of 88 patients treated with tocilizumab. Six SNPs previously described in the gene were genotyped (rs12083537, rs11265618, rs4329505, rs2228145, rs4537545, and rs4845625). Using parametric tests, we studied the association between the SNPs and hepatotoxicity, infection, hypersensitivity, gastrointestinal, hematological, and dyslipidemia adverse events (AEs). We found associations between dyslipidemia and rs4845625 and between hematological AEs and rs11265618 and rs4329505. No further associations were found for the remaining SNPs and other AEs. Our findings support the potential clinical value of SNPs in the gene as predictive biomarkers for toxicity to tocilizumab in patients with RA.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865948PMC
http://dx.doi.org/10.3390/jpm13010061DOI Listing

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