AI Article Synopsis
- Experimental studies indicate that growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels may impact tumor growth.
- Epidemiological research shows a potential connection between GH/IGF-1 status and cancer risk, though results are mixed.
- This review aims to summarize the long-term effects of GH replacement therapy on cancer risk in adults who have survived childhood cancer and sellar tumors.
Article Abstract
Experimental studies support the hypothesis that GH/IGF-1 status may influence neoplastic tissue growth. Epidemiological studies suggest a link between GH/IGF-1 status and cancer risk. However, several studies regarding GH replacement safety in childhood cancer survivors do not show a prevalence excess of de novo cancers, and several reports on children and adults treated with GH have not shown an increase in observed cancer risk in these patients. The aim of this review is to provide an at-a-glance overview and the state of the art of long-term effects of GH replacement on neoplastic risk in adults with growth hormone deficiency who have survived cancer and sellar tumors.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861672 | PMC |
| http://dx.doi.org/10.3390/jcm12020662 | DOI Listing |
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