AI Article Synopsis
- The study investigates how factors from the host (infant), microbes, and environment might affect the frequency of upper respiratory infections (URIs) in infants.
- Researchers analyzed saliva from 146 infants at 6 months old, measuring various biological components like cytokines and microbial RNA to find correlations with URI occurrences in their first year.
- Key findings linked URI frequency to environmental conditions (like daycare and air pollution), specific microbial presence, and molecular indicators from the infants, suggesting new ways to understand or manage URI risks in babies if confirmed in larger studies.
Article Abstract
Susceptibility to upper respiratory infections (URIs) may be influenced by host, microbial, and environmental factors. We hypothesized that multi-omic analyses of molecular factors in infant saliva would identify complex host-environment interactions associated with URI frequency. A cohort study involving 146 infants was used to assess URI frequency in the first year of life. Saliva was collected at 6 months for high-throughput multi-omic measurement of cytokines, microRNAs, transcripts, and microbial RNA. Regression analysis identified environmental (daycare attendance, atmospheric pollution, breastfeeding duration), microbial (Verrucomicrobia, Streptococcus phage), and host factors (miR-22-5p) associated with URI frequency (p < 0.05). These results provide pathophysiologic clues about molecular factors that influence URI susceptibility. Validation of these findings in a larger cohort could one day yield novel approaches to detecting and managing URI susceptibility in infants.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860840 | PMC |
| http://dx.doi.org/10.3390/ijms24020934 | DOI Listing |
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