AI Article Synopsis
- * Out of 2661 participants, 308 died during an average of 8.9 years of follow-up, and frail individuals had significantly lower survival rates compared to those who were pre-frail or robust.
- * Specifically, frail individuals were found to be 2.35 times more likely to die than robust individuals, indicating that frailty increases mortality risk regardless of other health factors.
Article Abstract
We aimed to investigate the association between frailty status and all-cause mortality in middle-aged and older people. We included 2661 individuals aged ≥ 35 from the Chilean National Health Survey 2009−2010. Mortality was determined through linkage with the Chilean Civil Registry and Identification. A 36-item frailty index (FI) was used to assess the frailty status. Associations between frailty status and all-cause mortality were assessed using Kaplan−Meier and Cox proportional hazard models adjusted for sociodemographic and lifestyle factors. A non-linear association was investigated using penalized cubic splines fitted in the Cox models. During an 8.9 median follow-up (interquartile range of 8.6−9.0), 308 individuals died (11.5%). Lower survival rates were observed in frail individuals compared to pre-frail and robust people (log-rank < 0.001). Compared with robust individuals, frail people had a higher mortality risk (HR: 2.35 [95% CI: 1.57 to 3.51]). Frail middle-aged individuals had a higher risk of dying independently of major risk factors.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859421 | PMC |
| http://dx.doi.org/10.3390/ijerph20021195 | DOI Listing |
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