AI Article Synopsis
- - Colorectal cancer (CRC), a prevalent cancer type linked to factors like chronic inflammation, was examined for its potential connection to Cheonggukjang (CJ), a traditional Korean fermented soybean known for its anti-inflammatory properties.
- - In a mouse model simulating colitis-associated colorectal cancer, CJ showed significant protective effects by reducing symptoms like colonic shortening and tumor formation, as well as by affecting inflammatory cytokine levels.
- - The study found that CJ not only improved gut integrity but also inhibited tumor growth by regulating cell processes like apoptosis and proliferation, showcasing its potential as an anti-cancer agent.
Article Abstract
Colorectal cancer (CRC) is the third most common type of cancer and is caused by multiple factors. Chronic inflammation, known to cause inflammatory bowel disease (IBD), is closely associated with CRC. Cheonggukjang (CJ), a traditional Korean fermented soybean, is a functional food with anti-inflammatory effects in the intestines, but its anti-cancer effects have not yet been explored. In this study, we investigated the cancer-protective effects of cheonggukjang in an azoxymethane/DSS (AOM/DSS)-induced colitis-associated colorectal cancer (CAC) mouse model. The CJ alleviated AOM/DSS-induced pathological symptoms such as colonic shortening, increased spleen weight, tumor formation, and histological changes. It also modulated pro-inflammatory and anti-inflammatory cytokine levels via the suppression of NF-κB and inflammatory mediator signaling pathways. Furthermore, the CJ improved intestinal integrity by regulating mucin-associated and tight junction proteins. In addition, it suppressed tumor growth by regulating apoptosis and proliferation. These results highlight the anti-tumor effects of CJ in an AOM/DSS-induced CAC mouse model.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858590 | PMC |
| http://dx.doi.org/10.3390/foods12020383 | DOI Listing |
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