AI Article Synopsis
- The study investigates how genetic variations in certain immunity-related genes influence susceptibility to pulmonary tuberculosis (PTB) and lymph node tuberculosis (LNTB).
- It analyzes 63 single nucleotide polymorphisms (SNPs) in various immune and cytokine genes, finding distinct genetic associations for each type of TB compared to healthy controls.
- The findings suggest that there are genetic components affecting the outcomes of TB infection, which could inform future research on susceptibility to both pulmonary and extra-pulmonary forms of the disease.
Article Abstract
Background: Tuberculosis (TB) manifests itself primarily in the lungs as pulmonary disease (PTB) and sometimes disseminates to other organs to cause extra-pulmonary TB, such as lymph node TB (LNTB). This study aimed to investigate the role of host genetic polymorphism in immunity related genes to find a genetic basis for such differences.
Methods: Sixty-three, Single nucleotide polymorphisms (SNPs) in twenty-three, TB-immunity related genes including eleven innate immunity (, , , , , , , , , ) and twelve cytokine (TNFA, , , , , , , , , , ) genes were investigated to find genetic associations in both PTB and LNTB as compared to healthy community controls. The serum cytokine levels were correlated for association with the genotypes.
Results: PTB and LNTB showed differential genetic associations. The genetic variants in the cytokine genes (, , , and and , associated with PTB susceptibility and cytokine levels but not LNTB ( < 0.05). Similarly, genetic variants in , , and showed susceptibility to LNTB and not PTB. Pathway analysis showed abundance of cytokine related variants for PTB and apoptosis related variants for LNTB.
Conclusions: PTB and LNTB outcomes of TB infection have a genetic component and should be considered for any future functional studies or studies on susceptibility to pulmonary and extra-pulmonary TB.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859508 | PMC |
| http://dx.doi.org/10.3390/genes14010207 | DOI Listing |
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Article Synopsis
- The study investigates how genetic variations in certain immunity-related genes influence susceptibility to pulmonary tuberculosis (PTB) and lymph node tuberculosis (LNTB).
- It analyzes 63 single nucleotide polymorphisms (SNPs) in various immune and cytokine genes, finding distinct genetic associations for each type of TB compared to healthy controls.
- The findings suggest that there are genetic components affecting the outcomes of TB infection, which could inform future research on susceptibility to both pulmonary and extra-pulmonary forms of the disease.
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J Xray Sci Technol
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Department of Radiology, Jiangxi Provincial People's Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China.
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